Management of paroxysmal cold haemoglobinuria: not only avoiding cold but also keeping warm

Paroxysmal cold haemoglobinuria and measles.

With the increasing control of congenital syphilis, paroxysmal cold haemoglobinuria has become a very rare disorder in childhood. Cases which occur now are more likely to be associated with acute infectious diseases (Kissmeyer-Nielsen and Schleisner, 1963). However, despite the frequency of measles in children, paroxysmal cold haemoglobinuria (PCH) has only previously been described as a compli...

Paroxysmal cold haemoglobinuria in syphilis patients.

A case of paroxysmal cold haemoglobinuria following chickenpox.

Investigations showed a very low Hb of 2.3 g/dl, platelet count of 3.89 x 109/l, and white cell count of 11.8 x 109/l (neutrophils 85%). Blood picture showed cold type HA, but failed to show any erythro-phagocytic neutrophils. She had a high ESR (125mm/hr) and high ferritin (312 nmol/l [ref. 0.27 0.337 nmol/l]) levels. Serum iron was 178 μmol/l, TIBC was 240 μmol/l and transferrin saturation wa...

Idiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.

Three examples of non-syphilitic paroxysmal cold haemoglobinuria (PCH) in children are described which occurred, within a period of 16 days, in association with a febrile illness. No definite viral aetiology or obvious epidemiological association could be established. A Donath-Landsteiner antibody of anti-P specificity was demonstrated in all three patients. The serological aspects of PCH are c...

Serological Findings in a Child with Paroxysmal Cold Haemoglobinuria

PCH is a rare autoimmune hemolytic anemia (AIHA) but is one of the most common causes of AIAH in children. For the diagnosis, it is important to perform the appropriate methods of serological investigation and show the typical biphasic reaction. This is a case report of a child who presented with features of haemolysis and was diagnosed with PCH of this way.